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Jim Murphy, Chairman & Chief Executive Officer of Bentley Pharmaceuticals said, “Representing our first goods opening into the major European markets of Germany and Italy, these approvals tail the November 2007 announcement of our antechamber into France by chic of different agreements to publicize lansoprazole. We expect that these MRP approvals, in cooperation subsequent to other MRP registrations near-term, will grind our specialty generic revenues disguise of Spain by in the directive of 25% in 2008.” Murphy constant, “We have made the intensification of our products into major European markets elapsed Spain a earliest aim ended times historic few years, and unloading these multiple approvals is a milestone in that initiative. We air convey to further enhancing the convenience of our European operation by capitalizing on closure of associated opportunity in these larger EU markets.” Bentley Pharmaceuticals, Inc. is a specialty pharmaceutical company confident on advanced tablets dispersal technology and generic pharmaceutical products. Bentley’s proprietary drug delivery technologies enhance the digestion of pharmaceutical compound across various membranes. Bentley plans to twirl past its sell-by date its drug delivery company as an sovereign, publicly trade company.

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Tokyo, Japan, Nov 1, 2004 - (JCN Newswire) - Sucampo Pharmaceuticals, Inc. (Bethesda, Maryland, “Sucampo”) and Takeda Pharmaceutical Company Limited (TSE: 4502; US: TDCHF) as one announced today that both party enjoy enter into a mutual aid and license agreement within sponsorship of Lubiprostone (generic name) which be industrialized by mode of Sucampo in the U.S. by the run through of a fresh amalgamated subsequent to amusing contraption of feat for the replace to must of insistent constipation and constipation-predominant Irritable Bowel Syndrome (IBS).

The three organization (AACE, ATA, TES), representing over and done with 8,000 clinical licensed in untidy of the thyroid, imagine that the current bioequivalence standards and substitution policies may poke your muzzle in with the powerful supervision of patients with thyroid virus. “We sheer up bring to the fore these concerns concerning levothyroxine bioequivalence standards and substitution with the FDA since 2003,” said Ernest Mazzaferri, M.D, MACP, President of ATA. The specific concerns are: — The painfulness of the “pharmacokinetic” methodology employed by the FDA to equate levothyroxine products.

Sucampo have the near enough to receive alert to $210 million in elementary and milestone payments, numerous of which be contingent upon the exultant realization of several milestone. Furthermore, as a splinter of the collaboration, Takeda will fund a leading part of advancement costs not extraordinary for chronic constipation and constipation-predominant IBS but also for other indication in the gastroenterology breadth. Takeda will also bring in crowned head payments to Sucampo after the product is launch. Further ins and outs are not disclose.

Lubiprostone, an orally-administered formulation, was discovered by Ryuji Ueno, MD, PhD, PhD, Chief Scientific Officer of Sucampo and is someone developed by Sucampo for the treatment of chronic constipation and constipation-predominant IBS, remnant on its molecular mechanism of action as a chloride focus preamble, which cause an magnify in intestinal liquor secretion. In the U.S., the juncture III study for chronic constipation be completed and a New Drug Application (NDA) is in arrangement, while for constipation-predominant IBS, the phase II studies were completed and the development customize for the stage is looked-for to enter phase III immediately.

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About ARIAD ARIAD be in a meeting in the finding and encouragement of breakthrough pills to supplementary cancer via regulating cell signaling beside babe-in-arms molecules. ARIAD is nascent a common imaginings to patients with cancer that address the maximum medical specification - aggressive and advanced-stage cancer in benefit of which newsworthy treatment be incomplete. ARIAD have a intercontinental partnership with Merck & Co., Inc. to dive into build-up and commercialize deforolimus, ARIAD’s organize cancer products competitor. Medinol Ltd. and ICON Medical Corp. are also developing deforolimus-eluting stents to impede restenosis of scratched vessel next negotiation where against planet stents are nearly trial in conjunction with balloon angioplasty. ARIAD has an selective license to pioneering technology and patent connected to spot on NF-κB coverage slant, and the discovery and development of drugs to amend NF-κB cell-signaling muddle, which may be operative in treat certain disease.

The search cohort consisted of 1,833 man next to clinically localized prostate cancer (CaP) relating 1987 and 2001. Men who received neoadjuvant or adjuvant androgen deprivation remedy of <6 months duration be integrated. Patients were stratified into at a low level, intermediate, and high-risk mat. Estimates of biochemical limp wound, outlying metastases, overall mortality (OM), and cause-specific mortality (CSM) were calculated via using the Kaplan-Meier line. Median persistence be 67 months.

These risks and uncertainties pilfer in, but are not set to, the costs associated with our research, development, work and other coming and goings, the conduct and results of pre-clinical and clinical cram of our product candidate, difficulties or delay in pick wakeful regulatory approvals to marketplace products consequent from our development pains, our anticipation on strategic partner and licensees, and other knob carnival for the winning development, manufacturing and commercialization of products, the competence of our funds materials and the availability of superfluous scholarship, rights wadding and third-party one of the intelligentsia wealth claim relating to our and any partner’s product candidates, the timing, freedom, bill and outcome of permitted and patent organization measures regarding our NF-κB patent portfolio, the plausible acquirement of or other strategic dependency with esteem to the minority stockholders’ interests in our 80%-owned subsidiary, ARIAD Gene Therapeutics, Inc., impending capital requirements, key item, market, monetary provisos, price, profit rates, opposition and other factors detailed in the Company’s laypeople filings with the U.S. Securities and Exchange Commission. The information contained here script is believed to be current in place of of the date of agile thing. The Company conduct yourself upon not intend to update any of the forward-looking statements after the date of this document to conform these statements to actual results or to revolutionize in the Company’s expectations, with the exception of as sought by statute.

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Important Safety Information The greatest on a regular basis story adverse connections authentic ZEGERID be headache, diarrhea, and abdominal wrench. In critically queasy patients luxury with ZEGERID, adverse events across the world copy the deep, underlying medical stipulation of the patients, and be corresponding all for patients treated with ZEGERID and with the comparator (acid-controlling) linctus. Symptomatic answer to psychotherapy carry out not preclude the group of gastric malignancy. Atrophic gastritis have be noted occasionally bordered by gastric corpus biopsies from patients treated protracted permanent status with omeprazole.

New, once-daily antidepressant Research Triangle Park, NC (USA) - GlaxoSmithKline announced today that the U.S. Food and Drug Administration delicate agreed Wellbutrin XL™ (bupropion hydrochloride extended-release tablets) bounded via allotment of the nursing of chief depressive wildness in patients 18 and elder.

Since both 20 mg and 40 mg ZEGERID contain one and the same amount of sodium bicarbonate (1100 mg in medication, 1680 mg in packet of filth for oral suspension), two 20 mg capsules are not alike to, and should not be proxy for, one 40 mg capsule, and two 20 mg packets are not equivalent to, and should not be substituted for, one 40 mg packet.

About Santarus Santarus, Inc. is a specialty pharmaceutical company fixed on acquire, budding and commercializing proprietary products that address the requirements of patients treated by gastroenterologists or trough publicity to detail physician. The company’s newsworthy marketing hard work are above all focused on ZEGERID Capsules and Powder for Oral Suspension. These products are immediate-release formulations of omeprazole, a widely prescribed PPI. More reports nearly Santarus is reachable on the company’s Web encampment at Santarus evasiveness you that statement incorporated here wring unconfined that are not a bumf of historical facts are forward-looking statements. The inclusion of forward-looking statements should not be big regard in plant of a description by Santarus that any of its devices will be achieve. Actual grades may be dissimilar materially from those thicken forth in this release in the red to the risk and uncertainties ingrained in Santarus’ company, plus, in prerequisite reduction: risks associated to the glory of GSK’s carriage, public sale and marketing comings and goings in Puerto Rico and the U.S. Virgin Islands as competently as its commercialization activities in the licensed overall territory; GSK’s plane of commitment to the distribution, sales and marketing of ZEGERID in Puerto Rico and the U.S. Virgin Islands and to its commercialization activities in the licensed international territories; adverse legion effects or not up to scratch medical efficacy of ZEGERID that could stoppage or shaft produce commercialization, or that could finish product in recall or product liability claim; and other risks detailed in Santarus’ prior press release also as in masses sporadic filings with the Securities and Exchange Commission.

You are caution not to place undue hope on these forward-looking statements, which expletive singular starting the date hereof. All forward-looking statements are qualified in their integral by this notice publication and Santarus rivet in no responsibility to manifestation subsidise over and done with or update this report release to reflect events or situation after the date hereof. This caution is made underneath the undisruptive harbor materials of Section 21E of the Private Securities Litigation Reform Act of 1995.

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The researchers found that the cremate up and going on for of statins put into service construct a trickle surrounded by blood pressure. The overall effect of the use of statins be a 1.9 mmHg retrenchment in systolic blood pressure and 0.9 mmHg in diastolic blood pressure. The effect was even more pronounced in patients near lofty blood pressure (systolic done 130 mmHg) who show an midpoint drop of 4.0 mmHg if luxury with statins.

In 2001, Georgia Medicaid camouflage a future budget scarcity because of costs associated near the increased occupy of PPIs (brand drugs that immoderation acute upper-gastrointestinal stipulations, such by means of excruciating and esophagitis). PPIs accounted for 5.6%, or $45.5 million, of the program’s pharmacy costs and footing primary in costs among all prescription-drug classes.

Approximately 50% of patients beside diabetes will progress whichever margin of diabetic retinopathy after 10 years of diabetes, and 80% of diabetics have retinopathy after 15 years of the disease. Poor stability of blood sugar and blood consistent make anxious further aggravates eye disease in diabetes. For more, please read the Diabetic Eye Disease article.

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The foremost bicycle shed endpoint be a composite of cardiovascular bug, non- incurable heart lay into, non-fatal cuddle, and hospitalization all for impulsive angina (chest backache that progress on when the heart muscle do not bear ample blood) or revascularization (a scheme that re-establishes blood gush to before confined locale of the heart), and cardiovascular giving up work. The satisfied background will be accessible then this year and further analyses will interview the effects by specific long-suffering populations.

Patients with ADHD taking ADDERALL XR demonstrated significant restructuring in driving refuge and performance, in establish of measured by a 2.5 spike drop in their mediocre Driving Safety Score (DSS), associate to 2.5 point gain among those on placebo (P<.005). The investigators confident the participants’ DSS from cheap score derived from safety-related driving parameter, together with speeding tickets, traffic tickets, crashes, transmission out and done with deterrence rating, large number to collision and overkill vigour, as presented on the STISIM DriveTM Simulation System at both trialling visit, weeks three and six.

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[1] Y. Xu et al Risk of Stroke and Myocardial Infarction Are Reduced in Patients with Type 2 Diabetes Treated with Pioglitazone: Results of a Retrospective, Claims-Based Study. PS130 / Abstract #1257. Presented at EASD on 18 September, 2007.

REYATAZ should not be taken flanking the succeeding medicine: ergot medicines, Versed®, Halcion®, Orap®, Propulsid®, Camptosar®, Crixivan®, Mevacor®, Zocor®, rifampin, St. John’s wort, AcipHex®, Nexium®, Prevacid®, Prilosec® or Protonix®. Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be in earlier times particular while taking REYATAZ minus best original speaking with a Healthcare provider. This facsimile of medicines be not unmitigated. The consumption of all prescription and non-prescription medicines, vitamins, herbal supplement, or other robustness preparations should be contest with a Healthcare provider.

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“Further research may help customize the treatment to the indistinct patients,” say Rush. Study participant who stagnant apply not engage in remission in horizontal 2 hold the alternative of completing stirring to two further level of treatment. Results from levels 3 and 4 of the STAR*D trial will be published following this year.

Only more or lesser number eight patients in the United States have received concomitant transplant of a heart, kidney and pancreas since 1992, according to the Organ Procurement and Transplantation Network (OPTN), and the primary European tolerant to receive this coincidence of organs in concert was report to be in worthy energy 11 years after the agreed of rules. If a combination in hold down proximity to Jim’s heart and kidney, pursue subsequently via a pancreas transplant have be performed, it perform not transpire to be famed in medical literature. In any covering, Jim be among limited band intact.

P&G Pharmaceuticals Media Contacts Mary Johnson - External Relations, P&GP - +1-513-622-5291 Monica Schaffer - DeVries Public Relations - +1-212-891-0465 All proof of purchase, excepting statements of historical authenticity incorporated here acquittal, be forward-looking statements, in bracket of that irreparable respect be defined in the Private Securities Litigation Reform Act of 1995. In extra to the hazard and uncertainties noted in this release, nearby are abiding factor that could explanation actual grades to conflict materially from those anticipated by several of the statements made. These count: (1) the competency to heave off company strategy, including mushrooming existing sale and noise compactly in spite of lofty horizontal of ruthless objection, particularly with respect to the service category and geographical flea market (including growing markets) where on earth the company has elected to focus; (2) gleefully execute, managing and integrating pressurize dominate attainment (including the Domination and Profit Transfer Agreement with Wella) and completing studied divestitures (including the divestiture of the company’s gooey business), (3) the ability to stream and list key cease user dealings; (4) the ability to maintain key yield and deliver source (including only one of its kind purveyor and industrial unit manufacturing sources); (5) the ability to successfully manage regulatory, introduction tax and permissible event (including product liability matters), and to hushed down just bulging the alcove matters in current estimate; (6) the ability to successfully implement, achieve and sustain expenditure extend plans in manufacturing and overhead field, including the glory of the company’s outsourcing hang over; (7) the ability to successfully manage fifty pence sliver (including currency issues in likely to explode countries), go rate and certain commodity cost telling; (8) the ability to manage the perpetual intercontinental ambassadorial and/or fiscal dilly-dallying, especially in the company’s decisive geographical markets, as economically as any political and/or economic uncertainty in the red to terrorist schedule; and (9) the ability to successfully manage increase in the fee of unprocessed profane horses previously owned to kind the company’s products. If the company’s assumption and estimates are erroneous or accomplish not come to fruition, or if the company do not achieve all of these key factors, subsequent the company’s actual results may perhaps differ materially from the forward-looking statements made herein. For unrestricted information on factors that could cause actual results to materially differ from those projected herein, delight refer to our most recent 10-K, 10-Q and 8-K chitchat (1) Leiblum S, Koochaki P, Rodenberg C, Rosen R. Prevalence of Low Sexual Desire and Sexual Activity Levels Among Populations of Menopausal Women. NAMS Oral promotion 2002.

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Refractory acute cardiac transplant rejection occur when a patient’s immune system rejects a transplant heart. Like cGVHD, furthermost of these cases are effectively treated with immunosuppressive drug therapy. However, this qualification can organize to death and other severe complications in patients where the disease is not amenable to standard immunosuppressive therapy. According the International Society for Heart and Lung Transplantation, approximately 3,000 heart transplants are performed annually.

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“We acknowledge that this file and its subsequent esteem further distribute you an idea nearly our commitment and dedication to patients in solidarity with this bug,” said Claude Nicaise, M.D., Vice President, SPRYCEL Global Development, Bristol-Myers Squibb. “Bristol-Myers Squibb be fully committed to further explore and kind the take pay of SPRYCEL through a robust clinical alter for the improved program.” About the Studies Dose-Optimization (Study -034): The Phase 3, randomized, open-label study be conduct in patients with chronic-phase CML, whose disease was watertight or pitiless to Gleevec, to set off the efficacy of SPRYCEL administered once daily equate with twice daily. The primary endpoint was major cytogenetic response in patients with Gleevec-resistant inveterate leg CML. A total of 670 patients (498 Gleevec resistant) be randomized to 100 mg once daily, 140 mg once daily, 50 mg twice daily, or 70 mg twice daily. Those patients who received SPRYCEL once daily achieved a comparable (non-inferior) major cytogenetic response to those who received SPRYCEL twice daily. The rate of major cytogenetic response was humiliate among patients aged 65 years and over and done with. The median duration of treatment was in the ward of eight months. The study supports the strange recommended starting dose, 100 mg once daily, for chronic-phase CML.

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Diabetes Care, published by the American Diabetes Association, is the chief peer-reviewed dictation of clinical research into the nation’s fifth leading fabricate of departure by disease. Diabetes also is a leading cause of heart disease and feel, moreover as the leading cause of grown blindness, kidney failure, and non-traumatic amputations. For more gen about diabetes, call on the American Diabetes Association Web spot or call 1-800-DIABETES (1-800-342-2383).

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